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KMID : 0352419940130010107
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Keimyung Medical Journal
1994 Volume.13 No. 1 p.107 ~ p.110
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Conservative treatment of unruptured tubal pregnancy with methotrexate
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Abstract
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Four subjects with unruptured tubal pregnancies were treated with four doses of intramuscular methotrexate (1.0mg/kg) followed by four doses of citrovorin factor (0.1mg/kg). The diagnosis was established in all cases by sonography and
radioimmunoassay
for serum β-subunit of human chorionic gonadotropin.
Subjects were followed with quantitative serum β-human chorionic gonadotropin radiommunoassay and sonography. Three of the four subjects experienced resolution of their ectopic pregnancy without additional surgical treatment. One subject
underwent
salpingectomy due to failure of medical treatment.
Further comparative studies and long-term follow-up are needed to evaluated reproductive outcome but the use of methotrexate seems to be valuable in the treatment of some selected cases of tubal pregnancy.
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KEYWORD
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